Rockland Immunochemicals Inc.´s anti-SARS-CoV Nucleocapsid (N) Protein (RABBIT) Antibody (200-401-A50) is a critical reagent for detection of SARS-CoV-2 in a variety of different immunoassays. This reagent can be applied to diagnostic testing for presence of Covid 19 in patient samples and also for use in drug discovery studies.
The SARS CoV-2 is part of a family of RNA encoded coronaviruses. It is also roughly 77% homologous to the SARS-CoV-1 Viral outbreak in 2003. The Nucleocapsid (N) protein has >90% homology to the 2003 SARS-Cov-1 virus N-protein.
A50 – Detecting CoV-2
Rockland produced Rabbit anti-CoV-1 Nucleocapsid protein in 2005 and it was raised to consensus sequence of known CoV-1 nucleocapsid proteins. The reactivity to SARS-CoV-2 has been confirmed by dozens of researchers around the globe and A50 is considered being the key antibody to detect SARS-CoV-2 in infected cells. The detection of CoV-2 has been verified using: ELISA, LF, WB, ICC/IF, IHC, Flow cytometry and IP. Also, diagnostic tests detecting antibody to the nucleocapsid protein of SARS-CoV-2 in patient samples have shown to be more sensitive than spike protein antibody for detecting early infection.
A50 in Nature
A recent Nature Research article authored by Volker Thiel lab (University of Bern) explains how a synthetic genomics platform has been used to clone SARS-CoV-2 and ultimately facilitate the screening of anti-viral compounds. This breakthrough was confirmed using Rockland´s Anti-SARS Nucleocapsid antibody, which detected the presence or absence of viral protein synthesis post SARS-CoV-2 infection both before and after the introduction of a broad-spectrum antiviral medication in Vero E6 cells.
This further shows the value of Rockland’s antibody for SARS-CoV-2 research. Don´t hesitate to give it a try!